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SUMMARY:Mechanisms of (phago)lysosomal resolution and homeostasis  - Dr Ro
 ni Levin Konigsberg (University of Cambridge)
DTSTART;VALUE=DATE-TIME:20260323T120000Z
DTEND;VALUE=DATE-TIME:20260323T130000Z
UID:https://new.talks.ox.ac.uk/talks/id/c41f8941-47ac-4bb5-8f21-0d7974030d
 77/
DESCRIPTION:Professional phagocytes internalise and degrade large amounts 
 of noxious materials. Consequently\, their endocytic systems are remarkabl
 y active\; macrophages take up > 20% of their volume hourly. A central que
 stion in our work is how these long-lived cells maintain function while pr
 ocessing diverse cargo. We focus on the endo-lysosomal system and have ide
 ntified SLC12A9 as a lysosomal ion co-transporter regulating lysosomal vol
 ume and fusion–fission balance\, with effects on degradative capacity\, 
 luminal pH and susceptibility to damage. Ongoing work aims to define the m
 echanisms that regulate this transport system and its roles in phagocyte f
 unction and lysosomal physiology.\nSpeakers:\nDr Roni Levin Konigsberg (Un
 iversity of Cambridge)
LOCATION:Kennedy Institute of Rheumatology (Kennedy Lecture Theatre)\, Hea
 dington OX3 7FY
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/c41f8941-47ac-4bb5-8f21-0d7974030d
 77/
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DESCRIPTION:Talk:Mechanisms of (phago)lysosomal resolution and homeostasis
   - Dr Roni Levin Konigsberg (University of Cambridge)
TRIGGER:-PT1H
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