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SUMMARY:Mechanism of Autophagy in Health and Disease - Professor Zvulun El
 azar (Weizmann Institute of Science)
DTSTART;VALUE=DATE-TIME:20240503T110000
DTEND;VALUE=DATE-TIME:20240503T120000
UID:https://new.talks.ox.ac.uk/talks/id/0d2605d7-c400-49bc-94b6-6303feda96
 c1/
DESCRIPTION:Autophagy eliminates cytoplasmic material by engulfment in mem
 branous vesicles targeted for lysosome degradation. Non-selective autophag
 y coordinates the sequestration of bulk cargo with the growth of the isola
 tion membrane (IM) through tight regulation of the rim aperture by PI(3)P.
  In yeast\, an obligate complex of Atg24/Snx4 with Atg20 or Snx41 assemble
 s at the IM rim in a spatially extended manner that depends on autophagic 
 PI(3)P. This assembly stabilizes the open rim to promote autophagic seques
 tration of large cargo in correlation with vesicle inflation. Constriction
  of the rim by the PI(3)P-dependent Atg2-Atg18 complex and clearance of PI
 (3)P by Ymr1 antagonizes rim opening and promotes autophagic maturation an
 d the consumption of small cargo. A second part of the talk will describe 
 new findings on Hereditary Sensory and Autonomic Neuropathy 9 (HSAN9)\, a 
 neurodegenerative disorder linked to mutations in tectonin β-propeller re
 peat-containing protein 2 (TECPR2) and characterized by an accumulation of
  mitochondrial ROS\, reduced mitochondrial membrane potential\, and elevat
 ed mitochondrial content that may arise from impaired autophagic clearance
  of aberrant mitochondria. Indeed\, loss of TECPR2 led to inhibition of Pi
 nk 1- and Parkin-dependent mitophagy. The accumulation of mitochondria and
  the immature mitochondrial content of autophagic vesicles in the brainste
 m of TECPR2 knockout mice matches these cellular observations. \n\n\nSpeak
 ers:\nProfessor Zvulun Elazar (Weizmann Institute of Science)
LOCATION:Dorothy Crowfoot Hodgkin Building (Seminar Room 2\, (20-138))\, o
 ff South Parks Road OX1 3QU
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/0d2605d7-c400-49bc-94b6-6303feda96
 c1/
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DESCRIPTION:Talk:Mechanism of Autophagy in Health and Disease - Professor 
 Zvulun Elazar (Weizmann Institute of Science)
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