BEGIN:VCALENDAR
VERSION:2.0
PRODID:talks.ox.ac.uk
BEGIN:VEVENT
SUMMARY:Generating Genetic Diversity - Dr Alexander Lorenz (The Institute 
 of Medical Sciences\, University of Aberdeen)
DTSTART;VALUE=DATE-TIME:20181121T150000Z
DTEND;VALUE=DATE-TIME:20181121T160000Z
UID:https://new.talks.ox.ac.uk/talks/id/68d8132b-569b-4dff-90b8-05d8cb2b4e
 16/
DESCRIPTION:\nSpeakers:\nDr Alexander Lorenz (The Institute of Medical Sci
 ences\, University of Aberdeen)
LOCATION:Dorothy Crowfoot Hodgkin Building (Main Seminar Room)\, off South
  Parks Road OX1 3QU
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/68d8132b-569b-4dff-90b8-05d8cb2b4e
 16/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Generating Genetic Diversity - Dr Alexander Lorenz (The I
 nstitute of Medical Sciences\, University of Aberdeen)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Generating Genetic Diversity - Dr Alexander Lorenz (The Institute 
 of Medical Sciences\, University of Aberdeen)
DTSTART;VALUE=DATE-TIME:20181121T150000Z
DTEND;VALUE=DATE-TIME:20181121T160000Z
UID:https://new.talks.ox.ac.uk/talks/id/68d8132b-569b-4dff-90b8-05d8cb2b4e
 16/
DESCRIPTION:\nSpeakers:\nDr Alexander Lorenz (The Institute of Medical Sci
 ences\, University of Aberdeen)
LOCATION:Dorothy Crowfoot Hodgkin Building (Main Seminar Room)\, off South
  Parks Road OX1 3QU
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/68d8132b-569b-4dff-90b8-05d8cb2b4e
 16/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Generating Genetic Diversity - Dr Alexander Lorenz (The I
 nstitute of Medical Sciences\, University of Aberdeen)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
BEGIN:VEVENT
SUMMARY:Role of the BRCA2-DSS1 Complex in Homologous Recombination - Profe
 ssor Patrick Sung (Professor of Molecular Biophysics and Biochemistry and 
 of Therapeutic Radiology\, Yale University)
DTSTART;VALUE=DATE-TIME:20151130T150000Z
DTEND;VALUE=DATE-TIME:20151130T160000Z
UID:https://new.talks.ox.ac.uk/talks/id/f8cce5b1-eb25-4635-baaa-c9d5ba4f63
 58/
DESCRIPTION:The exchange of the DNA binding protein RPA for the RAD51 reco
 mbinase on single-stranded DNA is a critical step in DNA break repair by h
 omologous recombination. This RPA-RAD51 handoff is dependent on the tumor 
 suppressor BRCA2. Importantly\, our work has shown that the BRCA2-associat
 ed DSS1\, a small\, highly acidic protein\, is also needed for this handof
 f process. Mechanistically\, DSS1 acts as a DNA mimic to attenuate the aff
 inity of RPA for DNA. Thus\, by targeting RPA and mimicking DNA\, DSS1 fun
 ctions with BRCA2 in a two-component homologous recombination mediator com
 plex in genome maintenance. \nSpeakers:\nProfessor Patrick Sung (Professor
  of Molecular Biophysics and Biochemistry and of Therapeutic Radiology\, Y
 ale University)
LOCATION:Dorothy Crowfoot Hodgkin Building (Main Seminar Room)\, off South
  Parks Road OX1 3QU
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/f8cce5b1-eb25-4635-baaa-c9d5ba4f63
 58/
BEGIN:VALARM
ACTION:display
DESCRIPTION:Talk:Role of the BRCA2-DSS1 Complex in Homologous Recombinatio
 n - Professor Patrick Sung (Professor of Molecular Biophysics and Biochemi
 stry and of Therapeutic Radiology\, Yale University)
TRIGGER:-PT1H
END:VALARM
END:VEVENT
END:VCALENDAR