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PRODID:talks.ox.ac.uk
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SUMMARY:Cerebrospinal and serum alpha-synuclein species as potential bioma
 rkers for Parkinson’s disease - Prof. Omar El-Agnaf (Qatar Biomedical Re
 search Institute)
DTSTART;VALUE=DATE-TIME:20170523T160000
DTEND;VALUE=DATE-TIME:20170523T170000
UID:https://new.talks.ox.ac.uk/talks/id/de72a164-99e0-4aa3-b94d-6f9df33747
 c9/
DESCRIPTION:Developing effective treatments for neurodegenerative diseases
  is one of the greatest medical challenges of the 21st century. Parkinson
 ’s disease (PD) and dementia with Lewy bodies (DLB) are very common neur
 ological disorders of the elderly.  Although many of these clinical entiti
 es have been recognized for more than a hundred years\, it is only during 
 the past fifteen years that the molecular events that precipitate the dise
 ases have begun to be understood. Mutations in the alpha-synuclein gene ca
 use early-onset PD\, often associated with dementia. Neuropathologically t
 hese diseases are characterized by the presence of Lewy bodies\, intraneur
 onal inclusions mostly composed of alpha-synuclein protein fibrils. Despit
 e the progress that has been made in understanding the underlying disease 
 mechanisms of PD and DLB\, there remains an urgent need to develop methods
  for use in diagnosis. The development of reliable surrogate markers for t
 he presence and abundance of alpha-synuclein lesions (Lewy bodies) in the 
 brain would naturally facilitate a more streamlined work-up during the ear
 ly care of PD and DLB patients\, and importantly\, allow for the biologica
 lly guided evaluation of future drug trials aimed at neuroprotection in th
 e synucleinopathies.  In this seminar\, I will present the progress which 
 has been made so far by our group to explore the use of CSF α-synuclein a
 nd its modified forms as biomarkers for PD and related disorders.\n\nAbout
  Prof Omar El-Agnaf:\nProf. El-Agnaf is considered a pioneer in the field 
 of Parkinson’s disease and related disorders. Several inventions have em
 erged from his research\, and his discoveries have greatly impacted the sc
 ientific research community\, provided further insight into the molecular 
 pathogenesis of Parkinson’s disease\, and offered new opportunities for 
 the development of novel diagnostic and therapeutic tools for Parkinson’
 s disease. His research has also been translated into clinical studies to 
 evaluate the potential use of α-synuclein in body fluids as diagnostic ma
 rker for Parkinson’s disease and related disorders.\nSpeakers:\nProf. Om
 ar El-Agnaf (Qatar Biomedical Research Institute)
LOCATION:Sherrington Building (Sherrington Small Lecture Theatre)\, off Pa
 rks Road OX1 3PT
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/de72a164-99e0-4aa3-b94d-6f9df33747
 c9/
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DESCRIPTION:Talk:Cerebrospinal and serum alpha-synuclein species as potent
 ial biomarkers for Parkinson’s disease - Prof. Omar El-Agnaf (Qatar Biom
 edical Research Institute)
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