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SUMMARY:Cancer Theme Seminar - Nancy Zaarour (NDWRH\, University of Oxford
 )\, Professor Karl Morten (Nuffield Department of Women's and Reproductive
  Health\, University of Oxford)
DTSTART;VALUE=DATE-TIME:20240604T130000
DTEND;VALUE=DATE-TIME:20240604T140000
UID:https://new.talks.ox.ac.uk/talks/id/47a20250-7d04-4f49-a993-e189a5fcdc
 e0/
DESCRIPTION:Nancy Zaarour\nTitle: Unleash the potential of T-cell mediated
  immune response within the Fallopian tube for ovarian cancer prevention.\
 nAbstract: High-grade serous ovarian cancer (HGSC) is the most lethal hist
 otype of ovarian cancer and most cases present with metastasis and late-st
 age disease. Over the last few decades\, the overall survival for patients
  has not significantly improved\, and there are limited targeted treatment
  options. The fallopian tube is now believed to be the origin of most high
  grade serous ovarian cancers. Exploring the anti-tumor potential of immun
 e cells in the fallopian tube is essential to implement preventative strat
 egies. In spite of documented evidence of immune cell infiltration of the 
 connective tissue surrounding serous tubal intraepithelial carcinomas (STI
 Cs)\, the ovarian cancer precursor\, the direct demonstration of the abili
 ty of tissue resident memory T cells (TRMs) in eliciting an anti-tumour im
 mune response has not been previously shown. In this talk\, we will discus
 s our recent findings showing how TRMs that reside in non-cancerous fallop
 ian tubes recall a memory response by reacting to tumour organoids derived
  from omental metastases in the same patient. Moreover\, these memory cell
 s induce apoptosis in tumour-derived organoids indicating that they posses
 s cytotoxic ability. We will also shed light on the discovery of a novel T
  cell subset with an immune-epithelial phenotype. Harnessing the power of 
 TRMs could guide the design of novel vaccination strategies to prevent ova
 rian cancer.\n\n\n\nKarl Morten\nTitle: Raman microspectroscopy: a new too
 l coming to a lab near you\nAbstract: Mass spectrometry (MS) has remained 
 the gold standard for metabolomics but requires destructive sample prepara
 tion and gives no spatial resolution within a sample. Raman spectroscopy i
 s a label-free spectroscopy method increasingly utilised in the biological
  field due to overcoming the limitations of MS. Each molecule in a biologi
 cal sample will have a different vibrational energy\, causing differential
  polarisation of photons and generate a different Raman ‘fingerprint’ 
 for each sample. For this reason\, Raman has been utilised in the study of
  biological samples\, with Raman bands able to identify important biologic
 al macromolecules\, metabolites\, and cell types\, requiring only single c
 ells for analysis. A clear Raman fingerprint correlating to a mitochondria
 l respiration (OXPHOS) or glycolysis signature could be utilised in the as
 sessment of cell metabolism in tumours.\n\nThrough manipulation of cell cu
 lture conditions\, we can generate distinct metabolic phenotypes in A549 a
 nd H460 non-small cell lung cancer lines\, which are either high in OXPHOS
  or glycolysis. Utilising Raman spectroscopy on whole cells and isolated m
 itochondria from these cell lines\, we show clear differences in Raman spe
 ctra\, particularly in bands correlating to cytochrome c molecules and ami
 no acids\, which could be attributed to differences in metabolism This has
  important implications in cancer research and our understanding of tumour
  metabolism\, with spatial assessment of metabolism within a tumour possib
 le. Furthermore\, with only single cells required rather than an invasive 
 biopsy in patients\, Raman spectroscopy could be a highly effective diagno
 stic tool for tumour metabolism in patients\, indicating which tumours may
  be sensitive to metabolism targeted therapies\, and allowing more individ
 ualised treatment.\nSpeakers:\nNancy Zaarour (NDWRH\, University of Oxford
 )\, Professor Karl Morten (Nuffield Department of Women's and Reproductive
  Health\, University of Oxford)
LOCATION:This event is hybrid
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/47a20250-7d04-4f49-a993-e189a5fcdc
 e0/
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DESCRIPTION:Talk:Cancer Theme Seminar - Nancy Zaarour (NDWRH\, University 
 of Oxford)\, Professor Karl Morten (Nuffield Department of Women's and Rep
 roductive Health\, University of Oxford)
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