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SUMMARY:Lister Institute Research Prize Lecture:  Genome maintenance versu
 s genome diversification: mechanisms governing the fate of DNA breaks - Dr
  Ross Chapman (University of Oxford)
DTSTART;VALUE=DATE-TIME:20200310T120000Z
DTEND;VALUE=DATE-TIME:20200310T130000Z
UID:https://new.talks.ox.ac.uk/talks/id/4dc64f96-a3b9-41ef-88b1-49531a894c
 83/
DESCRIPTION:Synopsis:  "DNA double-strand breaks (DSBs) are highly toxic a
 nd their accurate repair is essential for the prevention of human disease 
 and cancer. However\, in developing B and T lymphocytes\, mutagenic DSB re
 pair is instead favoured and mediates genetic recombination within antibod
 y/B cell and T cell receptor genes\, the result of which creates diversity
  in immune repertoire.  To cope with this intrinsic discrepancy in desired
  DNA repair outcome between different contexts and tissue types\, cells ha
 ve evolved complex regulatory systems that maintain an appropriate equilib
 rium between competing DNA repair pathways\, and that ensure DNA breaks ar
 e appropriately resolved. This talk will focus on my groups' recent resear
 ch into the molecular mechanisms that underpin a cell’s ability to selec
 t between accurate and mutagenic DNA repair pathways\, and will describe h
 ow understanding these processes can inform on the molecular basis of canc
 er and its response to therapy\nSpeakers:\nDr Ross Chapman (University of 
 Oxford)
LOCATION:Wellcome Trust Centre for Human Genetics (Seminar Rooms A&B )\, H
 eadington OX3 7BN
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/4dc64f96-a3b9-41ef-88b1-49531a894c
 83/
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DESCRIPTION:Talk:Lister Institute Research Prize Lecture:  Genome maintena
 nce versus genome diversification: mechanisms governing the fate of DNA br
 eaks - Dr Ross Chapman (University of Oxford)
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