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SUMMARY:A new rationale for TF paralog evolution\, expression and function
  - Professor Matthias Merkenschlager (Lymphocyte Development Group\, MRC C
 linical Sciences Centre\, London)
DTSTART;VALUE=DATE-TIME:20170403T130000
DTEND;VALUE=DATE-TIME:20170403T140000
UID:https://new.talks.ox.ac.uk/talks/id/6e6dc71f-f6e9-4553-8dc2-a3193d48ac
 d6/
DESCRIPTION:Gene duplications are major drivers in the evolution of biolog
 ical complexity\, but the forces that shape paralog evolution remain incom
 pletely understood. RUNX transcription factor paralogs are expressed in mu
 tually exclusive cell types\, sacrificing potential robustness conferred b
 y gene duplications without obvious gain. To elucidate this issue\, we exp
 lored two RUNX-dependent developmental branch points. In both settings\, R
 UNX paralogs differed in their functional properties\, providing a rationa
 le for selective paralog expression\, and allowing us to identify paralog-
 specific amino acids that modulate the strength of DNA binding and gene re
 gulatory control. Remarkably\, in both paradigms examined\, the non-endoge
 nously expressed paralog was biologically more potent than the endogenousl
 y expressed paralog\, increasing the generation of specialized cell types 
 regardless of environmental conditions. These findings suggest submaximal 
 regulatory control as a driver for transcription factor paralog evolution\
 , a conclusion supported by the evolutionary trajectory of RUNT domain res
 idues\, which indicates selection of sequences that moderate DNA binding a
 nd gene regulatory control. \nSpeakers:\nProfessor Matthias Merkenschlag
 er (Lymphocyte Development Group\, MRC Clinical Sciences Centre\, London)
LOCATION:Dorothy Crowfoot Hodgkin Building (Main Seminar Room)\, off South
  Parks Road OX1 3QU
TZID:Europe/London
URL:https://new.talks.ox.ac.uk/talks/id/6e6dc71f-f6e9-4553-8dc2-a3193d48ac
 d6/
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DESCRIPTION:Talk:A new rationale for TF paralog evolution\, expression and
  function - Professor Matthias Merkenschlager (Lymphocyte Development Grou
 p\, MRC Clinical Sciences Centre\, London)
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