Using genetic association to understand human biology

Patterns of genetic association have revealed much about the biology underlying human traits and complex diseases. But how can we use such information systematically to learn about the processes – at molecular, cellular and tissue levels – that modulate risk? I will discuss some challenges, approaches, and solutions to the problems of integrating and interpreting data on such a vast scale. And how such information can be applied to diverse problems ranging from therapeutic target identification to quantifying individual risk.