*CANCELLED* The Role of DOCK8 in B cell Immune Function

Status: This talk is in preparation - details may change
Status: This talk has been cancelled

This talk has been cancelled. Apologies for any inconvenience,

The DOCK8 Immunodeficiency Syndrome is characterised by a failure to generate long-term T cell dependent protective immunity, associated with absent affinity maturation. Our findings suggest that the absence of DOCK8 causesdefects downstream of the B cell receptor, which result in a failure of B-T cross-talk when antigen is limiting. These effects are associated with reduced B cell survival, which is amplified in the germinal centre.