Post translational modification of Beta2 glycoprotein I a major plasma glycoprotein in immunity and autoimmunity.
This seminar will be held using Zoom. Please register here:
Beta2 glycoprotein I (β2GPI) is an abundant plasma protein composed of 5 domains. The C-terminal disulphide bond is susceptible to cleavage by oxidoreductases. Certain biological functions of β2GPI depend on the redox form of the molecule. Nitric oxide metabolism has been shown to be disrupted in APS patients. We found that nitration of β2GPI occurs in-vivo and in-vitro in patients with APS and SLE and the nitrated form of the molecule alters its biological function. A novel assay was developed to quantify nitrated β2GPI levels. These were raised in patients with autoimmune disease compared to healthy and clinical event controls.
Date: 29 June 2020, 9:00 (Monday, 10th week, Trinity 2020)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: This seminar will be held using Zoom. Please register here:
Speaker: Professor Steven Krilis (Director of the Department of Infectious Disease, Immunology and Sexual Health, St. George Hospital, University of New South Wales, Australia)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jennifer Pope (Kennedy Institute of Rheumatology), Professor Irina Udalova (Kennedy Institute of Rheumatology)
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Host: Professor Kim Midwood (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Required
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Audience: Public
Editor: Jennifer Pope