"Microbiome and cell death mediated regulation of inflammatory immunity " Professor Tracy McGaha
There has been significant interest in defining mechanisms of microbiome-immune system crosstalk and its influence on therapy. We have identified a key role for tryptophan-derived microbial metabolites in induction of an immune-suppressive program in tissue-resident macrophages that attenuates T cell function promoting tumor growth. In this seminar I will describe mechanisms that are essential for microbiome-innate immune crosstalk, potential avenues of therapeutic intervention in this regulatory circuit, as well as recent developments in the field that reveal the challenging complexity of bacterial tryptophan metabolization, disease pathology, and the response to a variety of therapeutic modalities.
Date: 17 July 2023, 12:00 (Monday, 13th week, Trinity 2023)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Prof Tracy McGaha (University of Toronto)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Doris Chan (Kennedy Institute of Rheumatology), Wilby Chaplin (Kennedy Institute of Rheumatology), Jo Silva (NDORMS)
Host: Richard Williams (University of Oxford)
Part of: Kennedy Institute Seminars
Booking required?: Required
Booking url: https://medsci.zoom.us/meeting/register/tJMtcOGqqT8uHtMbi0nv8XKaK1h4XYFTJWH9
Audience: Members of the University only
Editor: Lola Chaplin