"Peptides and protons: How pH gradients link transport and trafficking in the cell."
Recently we determined the first crystal structure for the KDEL trafficking receptor, which functions to maintain the integrity of the ER and Golgi. The receptor functions by selectively retrieving folding chaperones, which contain a C-terminal KDEL retention signal, in a pH dependent manner from the Golgi back to the ER via COPI coated vesicles. The structure and associated functional insights reveal a remarkable and somewhat unexpected similarity to membrane transporters, which in contrast to trafficking receptors, function to shuttle nutrients and small molecules across a single membrane rather than between two separate membrane environments. In this talk I will present how these insights uniquely bring together what where once considered two different themes of cell biology, transport and trafficking, and discuss how these two systems share mechanisms for peptide recognition and proton coupling in the cell.
Date: 15 January 2020, 11:00 (Wednesday, 0th week, Hilary 2020)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Meeting rooms A & B
Speaker: Professor Simon Newstead (University of Oxford,)
Organising department: Wellcome Trust Centre for Human Genetics
Organiser: Agata Krupa (Wellcome Centre for Human Genetics, University of Oxford)
Organiser contact email address: strubiadmin@strubi.ox.ac.uk
Hosts: Prof E.Yvonne Jones (University of Oxford), Prof David Stuart (University of Oxford)
Part of: Strubi seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Agata Krupa