Selective Inference: The Silent Killer of Replicability
The replicability problems across varied scientific disciplines have attracted increasing attention in the last two decades. Selective inference, namely the unadjusted inference on the few promising ones, selected as such, is a major source of the problems. Unfortunately, the problem is ignored in many important and highly visible areas of science, and p-values and significance testing are being blamed. I will describe this attack, and the politics surrounding it, in some detail. After presenting this background, the talk will focus on new hierarchical FDR strategies to address selective inference, and on false coverage-statement rate confidence intervals. I shall demonstrate these in the contexts of genomic research, gene-brain associations, NEJM new guidelines as to secondary outcomes, and the Replicability Project in Psychology.
Date: 7 September 2023, 15:00 (Thursday, 20th week, Trinity 2023)
Venue: Venue to be announced
Speaker: Professor Yoav Benjamini (Tel Aviv University)
Organising department: Big Data Institute (NDPH)
Booking required?: Not required
Audience: Members of the University only
Editor: Isobel Young