Exploiting Macrophage Responses to Radiotherapy to Improve Tumour Control

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Dr. Edward “Ted” Graves is an Associate Professor with tenure of Radiation Oncology and, by courtesy, Radiology at Stanford University. A native of the California Bay Area, he graduated with BS and PhD degrees in Bioengineering from the University of California at Berkeley and San Francisco, respectively. His doctoral work evaluated the use of magnetic resonance imaging and spectroscopy to plan focal brain tumor radiation treatments and to monitor tumor and normal tissue response to irradiation. He then performed a postdoctoral fellowship in the Center for Molecular Imaging Research at Massachusetts General Hospital developing technologies for three-dimensional optical imaging of fluorescent molecular probes. Returning to California, Dr. Graves took a faculty position at Stanford and created the Imaging Radiobiology Laboratory to engineer and apply molecular imaging methods to study radiation biology and to improve clinical radiotherapy. His background in physics, engineering and biology has facilitated multidisciplinary investigation including development of molecular imaging probes, quantitation and segmentation of molecular imaging data, and application of these methods to understand molecular and physiologic aspects of radiation and tumor biology such as cell migration and proliferation, immune responses, oxygen concentrations, and metabolism. He has also led the development of technologies to deliver clinically-similar image-guided conformal radiotherapy to small animals and has applied it in preclinical systems to understand the biological effects of these treatments.