Small intestinal neuro-endocrine tumours - surgery and science in Cambridge

Simon Buczacki is an academic consultant colorectal surgeon at Addenbrooke’s Hospital, Cambridge. His clinical practice focusses on laparoscopic colorectal cancer surgery and he also leads for small intestinal neuroendocrine tumour surgery. Buczacki leads the Aero-Digestive Cancer Programme for the Cambridge Cancer Centre and is a Group Leader at the Cambridge Stem Cell Institute. He currently holds a Cancer Research UK Advanced Clinician Scientist Fellowship. Buczacki is also Fellow and Director of Studies for medicine at Clare College.

His lab is interested primarily in the role sub-clonal interactions play on colorectal cancer cell identity and behaviour. This focus is based on the premise that the behaviour of normal intestinal cells is often analogous to that seen in oncogenically transformed cells and thus, the lab studies the behaviour of progenitor and differentiated cells from normal intestinal tissues to provide insights into cancer cell behaviour. The lab is particularly interested in understanding the mechanisms and links behind cancer plasticity and identity switching and also studies the fundamental biology of neuro-endocrine tumours through organoid biology and mouse modelling.