T cells as regulators of germinal center kinetics
There is no virtual option for this seminar.
Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Driving the GC reaction are a specialized subset of T cells called T follicular helper (Tfh) cells. Tfh engage in cognate ineractions with GC B Cells, leading to GC expansion. However, it has become evident in later times that the GC harbors multiple subsets of T cells, and that they serve a role in controlling the rise and fall of the GC. We are investigating the role of different T cells in GC kinetics, and how this ultimately effects the quality of GC B cells.
Date: 11 September 2023, 12:00 (Monday, 21st week, Trinity 2023)
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Bernard Sunley Lecture Theatre
Speaker: Prof Johanne Tracey Jacobsen (University of Oslo)
Organising department: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers: Jo Silva (NDORMS), Doris Chan (Kennedy Institute of Rheumatology)
Organiser contact email address: doris.chan@kennedy.ox.ac.uk
Host: Dr Tal Arnon (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Doris Chan