Placenta-brain communication in preeclampsia. What we have learnt from preclinical models.

I am a medical doctor, and Doctor in Biomedical Sciences, Full professor in the University of Bio Bio (Chillan, Chile). I have been working for many years in the understanding of vascular alterations observed in mother, placenta and offspring exposed to preeclampsia. Currently, we are studying how the impaired function of the placenta may trigger a dysfunction in the brain vasculature, in particular in the formation of brain blood vessels and in the generation of the blood-brain barrier both in the mother and in the offspring.

The lecture will discuss our recent findings showing disruption of the blood-brain barrier mediated by placental extracellular vesicles in the mother; and the negative impact in brain angiogenesis in offspring from preeclampsia.