Next generation association studies for complex traits: Progress in understanding the genomic landscape of osteoarthritis

Osteoarthritis is a common complex disease with a substantial public health burden. The genetic causes and molecular pathways underpinning disease development remain largely unidentified. In this talk I will highlight recent successes in understanding the aetiopathogenesis of osteoarthritis through large scale studies linking electronic health records to genetics research, and promising functional genomics approaches for deciphering the processes that lead to disease development and progression.