Cross-regulation between the immune system and the extracellular matrix during lung pathology

In person only

Communication between our immune system and the ECM is essential for tissue health and when dysregulated can be a factor contributing to pathology. In conditions like asthma, inflammation is often a predictor of disease severity. However, our lab has shown that allergen-induced ECM remodelling still occurs in the absence of chronic inflammation. Rather, we have discovered ECM changes are induced and sustained by chitinase-like proteins, immune-associated molecules highly upregulated in inflammatory and fibrotic diseases. More broadly, we have begun to study spatial changes of key immune cells/mediators and ECM organisation in the lung to understanding immune-ECM crosstalk during disease.