Newton-Abraham Lecture 2023 - 'Lipids in prostate cancer pathobiology: friends and foes'

Please register by Friday 15 September 2023

Professor Massimo Loda is the David D. Thompson Professor and Chairman of Pathology and Laboratory Medicine at Weill Cornell Medicine; and Pathologist-in-Chief in the New York-Presbyterian-Weill Cornell Campus. For many years, he has served as a Senior Staff Pathologist at Brigham and Women’s Hospital, and Chair of the Department of Oncologic Pathology at Dana-Farber Cancer Institute. Furthermore, he is Professor Emeritus of Harvard Medical School and Newton-Abraham Professor at the University of Oxford, Lincoln College, UK. Professor Loda directed molecular pathology laboratories in various institutions and served as interim director of molecular pathology at Weill Cornell Medicine-Presbyterian Hospital. He has worked as a physician-scientist, performing clinical work as a genito-urinary pathologist as well as a molecular pathologist. For years, his laboratory has focused on metabolic alterations in prostate tumorigenesis, with specific interest in lipid metabolism and its regulation. This has lead to the identification of potential vulnerabilities in the metabolic reprogramming of lipid synthesis that occurs in tumors in general and in prostate cancer in particular. Clinical trials with inhibitors of the rate limiting Fatty Acid Synthase enzyme are currently underway. His approach is multidisciplinary, utilizing cell lines, orthotopic tumor xenograft, genetically engineered murine models, and human tumors.