Gamma-Band Oscillations and Schizophrenia: A Translational and Developmental Perspective

This is a special bonus seminar as part of the Department of Psychiatry’s seminar series, with Peter J. Uhlhaas (Charité Universitätsmedizin Berlin) presenting on ‘Gamma-Band Oscillations and Schizophrenia: A Translational and Developmental Perspective’, with Philip McGuire chairing, followed by a presentation from Elizabeth Scott (The University of Sydney), with Naomi Wray chairing.

There is converging evidence that 40-Hz Auditory Steady-State Responses (ASSRs) are robustly impaired in schizophrenia and could constitute a potential biomarker for characterizing circuit dysfunctions as well as enable early detection and diagnosis. Here, I will summarize findings from electro- and magnetoencephalographic studies in participants at clinical high risk for psychosis, patients with first-episode psychosis as well as patients with 22q11.2 deletion syndrome to identify the pattern of deficits across illness stages, the relationship with clinical variables, and the prognostic potential. Finally, data on genetics and developmental modifications will be reviewed, highlighting the importance of late modifications of 40-Hz ASSRs during adolescence, which are closely related to the underlying changes in GABA (gamma-aminobutyric acid) interneurons. Together, our review suggests that 40-Hz ASSRs may constitute an informative electrophysiological approach to characterize circuit dysfunctions in psychosis that could be relevant for the development of mechanistic biomarkers.

To join online, please use the Zoom link below: * * Meeting ID: 951 4471 5955 * Passcode: 462130