Single-cell and epigenetic approaches to define and regulate macrophages in atherosclerosis

In our work we are pursuing a better understanding of macrophage functioning in atherosclerosis and identification of approaches to suppress their detrimental effects in disease. In my talk I will discuss our recent progress using single cell RNAseq of human atherosclerotic plaques to define immune cell populations and their characteristics. Moreover, we are performing studies to identify epigenetic enzymes that are relevant in regulating macrophages in atherosclerotic disease.