Pathway to Parkinson’s Disease: A Tale of Two Genes

The Moore Laboratory investigates the molecular pathophysiology of Parkinson’s. The majority of Parkinson’s cases occur in a sporadic manner although 5 to 10 percent of cases are inherited, with causative mutations identified in at least eight genes. The Moore Laboratory studies the normal biology and pathobiology of gene products that cause inherited Parkinson’s, including the common leucine-rich repeat kinase 2 (LRRK2, PARK8), the retromer component VPS35 (PARK17), the E3 ubiquitin ligase parkin (PARK2), and the lysosomal P5-type ATPase ATP13A2 (PARK9).