Vaccine modalities for more effective immunisation

The Vaccine Formulation and Adjuvants group at the Jenner Institute in Oxford is focused on understanding and improving the immune response to vaccination through modulating the context and kinetics of delivering the vaccine antigen.
The seminar will cover recent published and unpublished data describing the mechanism of action of different vaccine adjuvants in the context of a leading malaria vaccine, and how triggering different innate pathways can lead to divergent yet equally effective adaptive responses in mice. The adjuvant-stimulated innate-adaptive pathways are validated and further explored in human lymph node tissue ex vivo, using transcriptomic and functional profiling. The talk will also cover the most recent advances on delivering prime-boost immunisation through a single injection using polymer microparticles encapsulating the booster-vaccine dose.