Small Molecule Transport for Life

Transporting small molecules across cell membranes is an essential process in cell physiology. The uptake
of glucose and the maintenance of intracellular pH are two fundamental processes carried out by most
cells. Here, I will present our multidisciplinary approach that has revealed important insights into the
mechanism of glucose (GLUT) uptake and Na+/H+ exchange, which are important transport systems for our
cells to utilize glucose as an energy source and for the regulation cytoplasmic and organellar pH. I will also
present our recent structural insights into a sperm-specific Na+/H+ exchanger regulated by voltage –
transforming the transporter into a signaling cascade that is essential in animals (metazoa) for sperm
motility and fertilization.
Nature (2024) 626: 963-974; Nature (2023) 623:193–201; Nature (2020) 578 (7794):321-325; Nature (2015)
526(7573):397-401; Nature (2013) 501(7468):573-7.venue.