Broad-spectrum SARS-CoV-2 prophylactics designed based on viral evolution prediction

The Cao Lab at BIOPIC, Peking University, and Changping Laboratory investigates humoral immunity and antibodies at single-cell and molecular levels, including:

Antibody response, immune escape, and immune imprinting in infectious diseases, including SARS-CoV-2
Development of antibody therapeutics and vaccines
Deciphering the relationship between targeting epitopes and functions of antibodies for various antigens
Computational and machine learning methods for modeling antibody-antigen interaction

A.Yisimayi et al.,Y. Cao, Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting. Nature (2023).​

Y. Cao et al., Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. Nature 614: 21-529. (2023). ​

Y. Cao et al., BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature 608: 593-602. (2022).​

Y. Cao et al., Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature. 602: 657-663. (2022).​

Y. Cao, et al., Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells. Cell. 182, 73-84.e16 (2020).