Molecular and structural determinants of Alpha-Synuclein aggregation, toxicity and pathology spreading in Parkinson's disease: From mechanisms to novel biomarkers and therapies


Professor Hilal Lashuel is an Associate Professor of Life Sciences and Director of the Laboratory of Chemical Biology of Neurodegeneration, Brain Mind Institute at the Swiss Federal Institute of Technology Lausanne, Switzerland.

Research efforts in Lashuel’s laboratory cover the following topics: (1) Elucidating the structural basis of amyloid-associated toxicity in neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases; (2) Developing innovative chemical approaches and novel tools to monitor and control protein folding, self-assembly and post-translational modification in vitro and in vivo; (3) Identifying and validating new therapeutic targets for treating Parkinson’s disease; (4) Developing novel therapeutic strategies to treat neurodegenerative diseases based on modulation of protein aggregation and clearance.