A brain-wide analysis of entorhinal projections

Complementary actions of the neocortex and the hippocampus enable encoding and long-term storage of experience dependent memories. Standard models for memory storage assume that sensory signals reach the hippocampus from superficial layers of the entorhinal cortex (EC). Deep layers of the EC on the other hand relay hippocampal outputs to the telencephalic structures including many parts of the neocortex. In this seminar I will present new insights into how entorhinal outputs to the brain are wired to disseminate hippocampal outputs to outside of the hippocampal area, introduce a new feedback route for hippocampal outputs and discuss the implications of these findings for learning and memory.