Dynamic Effects of Interleukin-6 and Glucocorticoids on Cancer Host Responses

Please note this is an Ad-Hoc seminar. This is a hybrid event - with the speaker attending in-person and viewable on Teams.

Tobias completed his PhD at LMB/CPE (Cambridge) with Alan Fersht, before completing medical oncology education and CRUK fellowships also in Cambridge. He re-located his group to Cold Spring Harbor Laboratory in 2018. His work focuses on the body’s dynamic response to disease, in particular to cancer. Utilizing laboratory and clinical research paired with statistical modelling and bioinformatics, he aims to decipher the connections between metabolism, behaviour, endocrinology, and immunology. Areas that he is focused include the mechanistic effects of interleukin-6 and glucocorticoid secretion in cancer progression and cachexia, a highly debilitating wasting syndrome of the whole body that is commonly experienced by patients with cancers. This approach reflects the idea that cancer cannot be either understood or treated by investigating tumours in isolation. Tobias currently co-directs the international CRUK Grand Challenge in Cancer Cachexia awarded in 2022.