Genes to clinic in an autoimmune disease

The JDRF/Wellcome Diabetes and Inflammation Laboratory at the Wellcome Centre for Human Genetics aims to identify and characterise type 1 diabetes risk regions of the human genome and use this information to identify disease mechanisms in order to target potential preventative and therapeutic strategies. Examples include enhancing immunomodulatory functions of the interleukin-2 pathway and preventing the loss of immune tolerance to insulin.