Visualising Pattern Recognition Receptor Signalling

Clare Bryant is Professor of Innate Immunity at the Department of Veterinary Medicine at the University of Cambridge. Her research focusses on using multidisciplinary approaches to determine the molecular mechanisms by which Pattern Recognition Receptors (PRRs) signal. She used super resolution microscopy to visualise formation of the inflammasome and the spatial orientation of its endogenous constituents. She is using single molecular florescent techniques to determine how Toll-like receptors signal in response to bacterial and endogenous ligands. She also uses more conventional experimental approaches to determine how PRRs influence the host immune response to Salmonella infection in vitro and in vivo.