Functional plasticity of CD4+ T cells is driven by an asymmetric inheritance of mitochondria

Steve Cobbold is Professor of Cellular Immunology at the Sir William Dunn School of Pathology, University of Oxford, where he continues to investigate how monoclonal antibodies can be used to therapeutically manipulate the immune system. He studied Biochemistry in Oxford, followed by a Ph.D. in Cambridge, which led to the first demonstrations of tolerance induction to proteins and then organ grafts using CD4 monoclonal antibodies in adult rodents. As part of the Waldmann group, he was also actively involved in the development of CAMPATH monoclonal antibodies, which are now used for the treatment of certain leukemias and for multiple sclerosis. He also developed statistical methods for the analysis of antibody clusters as used in the 3rd Human CD Antigen Workshop (1987) and in 1993 he organized the first Canine Leukocyte Antigen Workshop (CLAW). He was a scientific co-founder of TolerRx Inc., and together with Geoff Hale and Peppy Rebello, he co-founded BioAnaLab Ltd., a company that performs contract research and diagnostic testing for the biopharmaceutical industry, which was successfully sold to Merck/Millipore in 2009. He has published more than 250 articles and patents on the therapeutic applications of monoclonal antibodies and the mechanisms of transplantation tolerance. He recently suffered end stage renal failure and received a reciprocal paired donation kidney transplant with CAMPATH induction – perhaps the ultimate in clinical translation of his work?